陈继冰博士复大肿瘤医院生物治疗中心主任

姓名：陈继冰博士
职位：复大肿瘤医院生物治疗中心主任

【教育工作经历】

1996年—2001年就读于吉林大学白求恩医学部临床三系；

2001年－2002年工作于长春生物制品研究所乙肝疫苗室助理工程师；

2002年－2007年就读于吉林大学白求恩医学部免疫学教研室博士；

2007年—2011年工作于厦门大学医学院基础医学部微生物与免疫学学科群，讲师，主讲医学免疫学、医学微生物学；在厦门大学器官移植研究所从事科研工作，负责日常事务、基金申请、课题设计及文章写作等工作；

2011年9月赴美国休斯顿的MD Anderson肿瘤中心参观学习1周；2011年10月赴奥地利维也纳参加世界冷冻协会第16届年会，大会发言获优秀论文奖；

2011年至今就职于由徐克成总院长领导的广州复大肿癌医院专家团队之一，中心实验室，课题负责人；

【承担项目】

1．2006年“自身免疫调节因子AIRE在自身免疫耐受中的作用机制研究”项目获国家自然科学基金资助(编号：C03030102)，为第四申请人；

2． 2007年“抗CD40L及抗LFA1单抗在预防同种异体心脏移植排斥中的作用”获得厦门大学引进人才启动经费（3万元）资助，为第一申请人；

3．2008年“抗CD40L及抗LFA1单抗在预防胰岛异体移植排斥中的作用”获得厦门市自然科学基金项目(编号：3502Z20084013)，为第四申请人；

4．2008年“尼古丁刺激树突状细胞抗肿瘤机制研究”项目获得福建省自然科学基金项目，(编号：C0810040)，为第二申请人。

5．2008年 “对终末期糖尿病肾病患者行胰岛细胞－肾脏联合移植治疗的研究”项目获得福建省卫生教育联合攻关计划项目资助，（编号：WKJ2008-2-50），为第四申请人。

6．2010年“板蓝根组酸单体抗器官移植排斥及抗肿瘤双重作用的研究” 项目获得福建省科技计划重点项目支持 (编号：2010Y0052)，为第四申请人。

7．2010年“应用 Anti-DR5 mAb 分析TIPE2 对类风湿性关节炎联合免疫及凋亡的影响” 项目获得国家自然科学基金资助（面上项目，编号81072472），为第三申请人。

【发表论文】

1．Chen J (第一作者), Yang W, Yu C, Li Y. Autoimmune regulator initiates the expression of promiscuous genes in thymic epithelial cells. Immunol Invest. 2008;37(3):203-14. (IF=1.47)

2．Chen X, Shao W, Chen J (第三作者), Corbascio M, Qi Z. Allotransplantati on of sulphate glucomannan-alginate barium (SGA)-microencapsulated rat islets for the treatment of diabetes mellitus. Immunol Invest. 2009;38(7): 561-71. (IF=1.47)

3．Xie B, Chen J (联合第一作者), Xia J, Wang Y, Liang H, Ekberg H, Corbascio M, Qi Z. Combined costimulation blockade inhibites accelerated rejection mediated by alloantigen primed memory T cells in micel. Immunol Invest. 2009;38(7): 639-51. (IF=1.47)

4．Liang H, Liao C, Qi Z, Sha C, Xie B, Chen J (第六作者), Xia J, Wang Y, Yao Q, Zhao Y. Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4(+) memory T cells in mice. Transpl Immunol. 2010; 22(3-4): 128-36. (IF=2.44)

5．Wang Y, Qin Q, Chen J (联合第一作者), Kuang X, Xia J, Xie B, Wang F, Liang H, Qi Z. Synergistic effects of Isatis tinctoria L. and tacrolimus in the prevention of acute heart rejection in mice. Transpl Immunol. 2009; 22(1-2): 5-11. (IF=2.44)

6．Zhao Y, Zhang S, Zhou J, Wang J, Zhen M, Liu Y, Chen J (第七作者), Qi Z. The development of a tissue-engineered artery using decellularized scaffold and autologous ovine mesenchymal stem cells. Biomaterials. 2010;31(2): 296-307. (IF=7.43)

7．Liang H, Zhao Y, Shan Z, Liao C, Sha C, Xie B, Chen J (第六作者), Xia J, Wang Y, Qi Z. The recall alloresponse following retransplantation is more intense compared with the T cell memory-transfer model.Immunol Invest. 2010; 39(1): 39-53. (IF=1.47)

8．Xie B, Chen J (联合第一作者), Wang F, Lan T, Wang Y, Xia J, Li Z, Xie Q, Huang R, Qi Z. Monoclonal antibody treatment to prolong the secondary cardiac allograft survival in alloantigen-primed mice. Scand J Immunol, 2010;71(5):345-52. (IF=2.11)

9．Kang X, Chen J (联合第一作者), Qin Q, Wang F, Wang Y, Lan T, Xu S, Wang F, Xia J, Ekberg H, Qi Z, Liu Z.Isatis tinctoria L. combined with co-stimulatory molecules blockade prolongs survival of cardiac allografts in alloantigen-primed mice. Transpl Immunol. 2010; 23 (1-2): 34-9. (IF=2.44)

10．Lan T, Chen J (联合第一作者), Xia J, Wang Y, Xie B, Wang F, Qi Z. Inhibition of alloantigen-primed memory CD4+ and CD8+ T cells by hematopoietic chimerism in mice. Scand J Immunol. 2010; 72(2): 86-93. (IF=2.11)

11．Su Z, Xia J, Shao W, Cui Y, Tai S, Ekberg H, Corbascio M, Chen J (联合通讯作者), Qi Z. Small islets are essential for successful intraportal transplantation in a diabetes mouse model. Scand J Immunol. 2010; 72(6): 504-10. (IF=2.11)

12．Xu S, Chen J (联合第一作者), Wang F, Kang X, Lan T, Wang F, Li Z, Qi Z. Arsenic trioxide combined with co-stimulatory molecule blockade prolongs survival of cardiac allografts in alloantigen-primed mice. Transpl immunol. 2010; 24(1): 57-63. (IF=2.44)

13．Shao W, Chen J (联合第一作者), Wang F, Xia J, Qi Z. Combined application of blocking antibodies and microRNA interference in inhibiting CD44 Expression. Transpl P. 2010; 42(7): 2777–81. (IF=1.06)

14．Wang F, Chen J (联合第一作者), Shao W, Xie B, Wang Y, Lan T, Thorlacius H, Qi Z. Anti-CD44 Monoclonal Antibody Inhibits Heart Transplant Rejection Mediated by Alloantigen-primed CD4+Tm in Nude Mice. Immunol Invest. 2010; 39(8): 807-10. (IF=1.47)

15．Xia J, Chen J (第二作者), Shao W, Lan T, Wang Y, Xie B, Thorlacius H, Tian F, Huang R, Qi Z. Suppressing memory T cell activation induces islet allograft tolerance in alloantigen-primed mice. Transpl Int. 2010; 23(11):1154-63. (IF=3.25)

16．Chen J (第一作者), Xia J, Axelsson B, Fritzson I, Ekberg H, T?rngren M, Qi Z, Xing J. An N-(alkylcarbonyl)anthranilic acid derivative prolongs cardiac allograft survival synergistically with cyclosporine A in a high-responder rat model. Transpl immunol. 2010, 23(4): 180-4. (IF=2.44)

17．Huang Y, Wang Y, Chen J (联合第一作者), Wang F, Kang X, Xia J, Lan T, Xie B, Ekberg H, Wang X, Qi Z. Prevention of acute and chronic allograft rejection by combinations of tolerogenic dendritic cells. Scand J Immunol. 2010; 73(2): 91-101. (IF=2.11)

18．Wang F, Xia J, Chen J (联合第一作者), Peng Y, Cheng P, Ekberg H, Wang X, Qi Z. Combination of antibodies inhibits accelerated rejection mediated by memory T cells in xenoantigen-primed mice. Xenotransplantation. 2010; 17(6): 460-8. (IF=2.29)

19．Wang F, Chen J (联合第一作者), Shao W, Kang X, Xu S, Xia J, Dai H, Peng Y, Thorlacius H, Xing J, Qi Z. The major histocompatibility complex (MHC) of the secondary transplant tissue donor influences the cross-reactivity of alloreactive memory cells. Scand J Immunol. 2011; 73(): 190-7. (IF=2.11)

20．Cheng P, Xia J, Wang H, Chen J(第四作者), Wang F, Zhang Y, Huang X, Zhang Q, Qi Z. Islet transplantation reverses the effects of maternal diabetes on mouse oocytes. Reproduction. 2011; 141(4): 417-24. (IF=3.07)

21．Peng Y, Chen J (联合第一作者), Shao W, Wang F, Dai H, Cheng P, Xia J, Wang F, Huang R, Zhu Q, Qi Z. Xenoreactive CD4(+) memory T cells resist inhibition by anti-CD44 mAb and reject islet grafts via a Th2-dependent pathway. Xenotransplantation. 2011; 18(4): 252-61.

22．Dai H, Chen J (联合第一作者), Shao W, Wang F, Xu S, Peng Y, Lin Y, Xia J, Ekberg H, Wang X, Qi Z. Blockade of CD27/CD70 pathway to reduce the generation of memory T cells and markedly prolong the survival of heart allografts in presensitized mice. Transpl Immunol. 2011; 24(4): 195-202.

23．Shao W, Chen J (联合第一作者), Dai H, Peng Y, Wang F, Xia J, Thorlacius H, Zhu Q, Qi Z. Combination of monoclonal antibodies with DST inhibits accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice. Immunol Lett. 2011; 138(2): 122-8.

24．Lin Y, Dai H, Su J, Yan G, Xi Y, Ekberg H, Chen J (联合通讯作者), Qi Z. Arsenic trioxide is a novel agent for combination therapy to prolong heart allograft survival in allo-primed T cells transferred mice.Transpl Immunol. 2011;25(4):194-201.